5ZML

Stapled-peptides tailored against initiation of translation

5ZML の概要

• エントリーDOI: 10.2210/pdb5zml/pdb
• 分子名称: Eukaryotic translation initiation factor 4E, ACE-LYS-LYS-ARG-TYR-SER-ARG-MK8-GLN-LEU-LEU-MK8-PHE-ARG-ARG, NITRATE ION, ... (5 entities in total)
• 機能のキーワード: cap dependent translation, rna binding protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 24631.08

構造登録者

Lama, D.,Liberator, A.,Frosi, Y.,Nakhle, J.,Tsomia, N.,Bashir, T.,Lane, D.P.,Brown, C.J.,Verma, C.S.,Auvin, S.,Yano, J. (登録日: 2018-04-04, 公開日: 2019-02-20, 最終更新日: 2023-11-22)

• 主引用文献: Lama, D.,Liberatore, A.M.,Frosi, Y.,Nakhle, J.,Tsomaia, N.,Bashir, T.,Lane, D.P.,Brown, C.J.,Verma, C.S.,Auvin, S.; Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein.; Chem Sci, 10:2489-2500, 2019; PubMed: 30881679; DOI: 10.1039/c8sc03759k

実験手法

X-RAY DIFFRACTION (1.8 Å)