5ZMB

A-ubiquitin like protein from the trypanosoma brucei

5ZMB の概要

• エントリーDOI: 10.2210/pdb5zmb/pdb
• NMR情報: BMRB: 36175
• 分子名称: ubiquintin-like protein (1 entity in total)
• 機能のキーワード: structure from cyana 3.0, protein binding
• 由来する生物種: Trypanosoma brucei brucei TREU927
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 9141.47

構造登録者

Mi, J.,Tu, X.M. (登録日: 2018-04-02, 公開日: 2018-08-15, 最終更新日: 2024-05-15)

主引用文献

Mi, J.,Zhang, J.,Liao, S.,Tu, X.
Solution structure of a ubiquitin-like protein from Trypanosoma brucei
Protein Sci., 27:1831-1836, 2018

PubMed Abstract: Ubiquitin-like proteins, similar to ubiquitin, can either exist freely or be covalently attached to other proteins via an enzymatic cascade. The ubiquitin-like proteins play roles in multiple biological processes including transcription, stress responses, DNA repair and so on. In this study, a novel ubiquitin-like protein (TbUbl11) was identified in Trypanosoma brucei. The solution structure of TbUbl11 was solved by NMR spectroscopy. TbUbl11 adopts a conserved β-grasp fold composed by a five-stranded β-sheet curling around a central α-helix, similar to other ubiquitin-like proteins. Meanwhile, some differences between TbUbl11 and other ubiquitin-like proteins were also identified. Additionally, we revealed that TbUbl11 is located in the whole cell body of procyclic-form T. brucei.

PubMed: 30058168
DOI: 10.1002/pro.3492

実験手法

SOLUTION NMR