5ZMA

Structural basis for an allosteric Eya2 phosphatase inhibitor

5ZMA の概要

• エントリーDOI: 10.2210/pdb5zma/pdb
• 分子名称: Eyes absent homolog 2, 3-fluoro-N'-[(E)-{5-[(pyrimidin-2-yl)sulfanyl]furan-2-yl}methylidene]benzohydrazide (2 entities in total)
• 機能のキーワード: eya2, eyes absent protein, phosphatase, transcription coactivator, transcription
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 100106.09

構造登録者

Anantharajan, J.,Jansson, A.E.,Kang, C. (登録日: 2018-04-02, 公開日: 2019-06-05, 最終更新日: 2023-11-22)

• 主引用文献: Anantharajan, J.,Zhou, H.,Zhang, L.,Hotz, T.,Vincent, M.Y.,Blevins, M.A.,Jansson, A.E.,Kuan, J.W.L.,Ng, E.Y.,Yeo, Y.K.,Baburajendran, N.,Lin, G.,Hung, A.W.,Joy, J.,Patnaik, S.,Marugan, J.,Rudra, P.,Ghosh, D.,Hill, J.,Keller, T.H.,Zhao, R.,Ford, H.L.,Kang, C.; Structural and Functional Analyses of an Allosteric EYA2 Phosphatase Inhibitor That Has On-Target Effects in Human Lung Cancer Cells.; Mol.Cancer Ther., 18:1484-1496, 2019; PubMed: 31285279; DOI: 10.1158/1535-7163.MCT-18-1239

実験手法

X-RAY DIFFRACTION (3.175 Å)