5ZJZ

Stapled-peptides tailored against initiation of translation

Summary for 5ZJZ

DescriptorEukaryotic translation initiation factor 4E, Eukaryotic translation initiation factor 4 gamma 1, 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, ... (4 entities in total)
Functional Keywordscap dependent translation, rna binding protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight24636.81
Authors
Primary citation
Lama, D.,Liberator, A.,Frosi, Y.,Nakhle, J.,Tsomia, T.,Bashir, T.,Lane, D.P.,Brown, C.J.,Verma, C.S.,Auvin, S.
Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein
Chem Sci, 2019
DOI: 10.1039/c8sc03759k
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.67 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.22610 1.7% 1.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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