5ZH5

CRYSTAL STRUCTURE OF PfKRS WITH INHIBITOR CLADO-2

Summary for 5ZH5

Entry DOI	10.2210/pdb5zh5/pdb
Descriptor	Lysine--tRNA ligase, LYSINE, (3S)-6,8-dihydroxy-3-{[(2R,6S)-6-methyloxan-2-yl]methyl}-3,4-dihydro-1H-2-benzopyran-1-one, ... (4 entities in total)
Functional Keywords	krs, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Biological source	Plasmodium falciparum NF54 (Plasmodium falciparum (isolate NF54))
Total number of polymer chains	2
Total formula weight	118328.36
Authors	Babbar, P.,Malhotra, N.,Sharma, M.,Harlos, K.,Reddy, D.S.,Manickam, Y.,Sharma, A. (deposition date: 2018-03-11, release date: 2018-06-27, Last modification date: 2023-11-22)
Primary citation	Das, P.,Babbar, P.,Malhotra, N.,Sharma, M.,Jachak, G.R.,Gonnade, R.G.,Shanmugam, D.,Harlos, K.,Yogavel, M.,Sharma, A.,Reddy, D.S. Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite J. Med. Chem., 61:5664-5678, 2018 Cited by PubMed: 29779382 DOI: 10.1021/acs.jmedchem.8b00565 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.08 Å)

Structure validation