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5ZGR

Crystal structure of NDM-1 at pH7.3 (HEPES) in complex with hydrolyzed ampicillin

Summary for 5ZGR
Entry DOI10.2210/pdb5zgr/pdb
Related5ZGE 5ZGP 5ZGQ
DescriptorMetallo-beta-lactamase type 2, ZINC ION, (2R,4S)-2-[(R)-{[(2R)-2-amino-2-phenylacetyl]amino}(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, ... (5 entities in total)
Functional Keywordsndm-1, metallo-beta-lactamase, antibiotic resistent, conformational change, hydrolase-antibiotic complex, hydrolase/antibiotic
Biological sourceKlebsiella pneumoniae
Total number of polymer chains2
Total formula weight52352.21
Authors
Zhang, H.,Hao, Q. (deposition date: 2018-03-10, release date: 2018-08-22, Last modification date: 2023-11-22)
Primary citationZhang, H.,Ma, G.,Zhu, Y.,Zeng, L.,Ahmad, A.,Wang, C.,Pang, B.,Fang, H.,Zhao, L.,Hao, Q.
Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1.
Antimicrob. Agents Chemother., 62:-, 2018
Cited by
PubMed: 30150473
DOI: 10.1128/AAC.01579-18
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.15 Å)
Structure validation

217705

數據於2024-03-27公開中

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