5ZGP

Crystal structure of NDM-1 at pH6.2 (Bis-Tris) in complex with hydrolyzed ampicillin

Summary for 5ZGP

• Entry DOI: 10.2210/pdb5zgp/pdb
• Related: 5ZGE
• Descriptor: Metallo-beta-lactamase type 2, ZINC ION, DI(HYDROXYETHYL)ETHER, ... (6 entities in total)
• Functional Keywords: ndm-1, metallo-beta-lactamase, antibiotic resistent, conformational change, hydrolase-antibiotic complex, hydrolase/antibiotic
• Biological source: Klebsiella pneumoniae
• Total number of polymer chains: 2
• Total formula weight: 52458.33

Authors

Zhang, H.,Hao, Q. (deposition date: 2018-03-10, release date: 2018-08-22, Last modification date: 2023-11-22)

• Primary citation: Zhang, H.,Ma, G.,Zhu, Y.,Zeng, L.,Ahmad, A.,Wang, C.,Pang, B.,Fang, H.,Zhao, L.,Hao, Q.; Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1.; Antimicrob. Agents Chemother., 62:-, 2018; PubMed: 30150473; DOI: 10.1128/AAC.01579-18

Experimental method

X-RAY DIFFRACTION (1.15 Å)