5ZGE

Crystal structure of NDM-1 at pH5.5 (Bis-Tris) in complex with hydrolyzed ampicillin

Replaces:  3Q6X

Summary for 5ZGE

DescriptorMetallo-beta-lactamase type 2, (2R,4S)-2-[(R)-{[(2R)-2-amino-2-phenylacetyl]amino}(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, ZINC ION, ... (5 entities in total)
Functional Keywordsndm-1, metallo-beta-lactamase, antibiotic resistent, conformational change, antibiotic, hydrolase-antibiotic complex, hydrolase/antibiotic
Biological sourceKlebsiella pneumoniae
Total number of polymer chains2
Total molecular weight52294.13
Authors
Zhang, H.,Hao, Q. (deposition date: 2018-03-08, release date: 2018-08-22, Last modification date: 2018-12-12)
Primary citation
Zhang, H.,Ma, G.,Zhu, Y.,Zeng, L.,Ahmad, A.,Wang, C.,Pang, B.,Fang, H.,Zhao, L.,Hao, Q.
Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1.
Antimicrob. Agents Chemother., 62:-, 2018
PubMed: 30150473 (PDB entries with the same primary citation)
DOI: 10.1128/AAC.01579-18
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.14410 1.4% 5.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 5zge
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Molmil generated image of 5zge
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Molmil generated image of 5zge
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More Biological unit images

Molmil generated image of 5zge
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Molmil generated image of 5zge
rotated about x axis by 90°
Molmil generated image of 5zge
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (5zge.pdb1.gz [89.99 KB])
Coordinate files for Biological unit (5zge.pdb2.gz [90.63 KB])