5ZFB
Structure of human dihydroorotate dehydrogenase in complex with ascofuranone (open-form)
Summary for 5ZFB
Entry DOI | 10.2210/pdb5zfb/pdb |
Descriptor | Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (7 entities in total) |
Functional Keywords | rossmann fold, dihydroorotate/orotate, ubiquinone/ubiquinol, mitochondrial inner membrane, inhibitor complex, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 44305.20 |
Authors | Miyazaki, Y.,Inaoka, K.D.,Shiba, T.,Saimoto, H.,Amalia, E.,Kido, Y.,Sakai, C.,Nakamura, M.,Moore, L.A.,Harada, S.,Kita, K. (deposition date: 2018-03-02, release date: 2018-09-26, Last modification date: 2023-11-22) |
Primary citation | Miyazaki, Y.,Inaoka, D.K.,Shiba, T.,Saimoto, H.,Sakura, T.,Amalia, E.,Kido, Y.,Sakai, C.,Nakamura, M.,Moore, A.L.,Harada, S.,Kita, K. Selective Cytotoxicity of Dihydroorotate Dehydrogenase Inhibitors to Human Cancer Cells Under Hypoxia and Nutrient-Deprived Conditions. Front Pharmacol, 9:997-997, 2018 Cited by PubMed: 30233375DOI: 10.3389/fphar.2018.00997 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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