5ZEQ

Carboxypeptidase B in complex with DD28

5ZEQ の概要

• エントリーDOI: 10.2210/pdb5zeq/pdb
• 分子名称: Carboxypeptidase B, ZINC ION, (2~{S})-2-[(6-azanyl-5-chloranyl-pyridin-3-yl)methyl]-3-selanyl-propanoic acid, ... (5 entities in total)
• 機能のキーワード: selenium, organoselenium, selenol, cpb inhibitor, selectivity, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Sus scrofa (Pig)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35426.12

構造登録者

Itoh, T.,Yoshimoto, N.,Yamamoto, K. (登録日: 2018-02-27, 公開日: 2018-06-20, 最終更新日: 2018-07-04)

• 主引用文献: Itoh, T.,Yoshimoto, N.,Hirano, Y.,Yamamoto, K.; Structural basis for the selective inhibition of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) by a selenium-containing inhibitor with chloro-aminopyridine as a basic group; Bioorg. Med. Chem. Lett., 28:2256-2260, 2018; PubMed: 29859906; DOI: 10.1016/j.bmcl.2018.05.042

実験手法

X-RAY DIFFRACTION (1.9 Å)