5ZEO

X-ray structure of sperm whale V21C/V66C/F46S myoglobin mutant with an intramolecular disulfide bond

5ZEO の概要

• エントリーDOI: 10.2210/pdb5zeo/pdb
• 分子名称: Myoglobin, PROTOPORPHYRIN IX CONTAINING FE (3 entities in total)
• 機能のキーワード: myoglobin, sperm whale, oxygen transport
• 由来する生物種: Physeter catodon (Sperm whale)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17799.37

構造登録者

Yuan, H. (登録日: 2018-02-27, 公開日: 2018-05-09, 最終更新日: 2024-10-09)

主引用文献

Yin, L.L.,Yuan, H.,Du, K.J.,He, B.,Gao, S.Q.,Wen, G.B.,Tan, X.,Lin, Y.W.
Regulation of both the structure and function by a de novo designed disulfide bond: a case study of heme proteins in myoglobin
Chem. Commun. (Camb.), 54:4356-4359, 2018

PubMed Abstract: A de novo designed intramolecular disulfide bond in myoglobin, resembling that in cytoglobin without structural evidence, was confirmed by an X-ray structure for the first time and was demonstrated to regulate both the structure and function of this protein, which fulfills the design of an artificial dehaloperoxidase, with an activity exceeding that of a native enzyme.

PubMed: 29645029
DOI: 10.1039/c8cc01646a

実験手法

X-RAY DIFFRACTION (1.77 Å)