5ZCX

Structure of T20/N39

5ZCX の概要

• エントリーDOI: 10.2210/pdb5zcx/pdb
• 分子名称: Envelope glycoprotein, Envelope glycoprotein gp160 (3 entities in total)
• 機能のキーワード: 6-hb, helices, sugar binding protein
• 由来する生物種: Human immunodeficiency virus 1; 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 26153.30

構造登録者

Zhang, X.J.,Ding, X.H. (登録日: 2018-02-21, 公開日: 2018-10-10, 最終更新日: 2024-10-30)

主引用文献

Zhang, X.,Ding, X.,Zhu, Y.,Chong, H.,Cui, S.,He, J.,Wang, X.,He, Y.
Structural and functional characterization of HIV-1 cell fusion inhibitor T20.
AIDS, 33:1-11, 2019

PubMed Abstract: The peptide drug T20 (enfuvirtide), derived from the C-terminal heptad repeat region of HIV-1 gp41, is the only membrane fusion inhibitor available for treatment of viral infection; however, its mechanism of action remains elusive and its structural basis is lacking.

PubMed: 30096076
DOI: 10.1097/QAD.0000000000001979

実験手法

X-RAY DIFFRACTION (2.299 Å)