5ZAN

Crystal Structure of Aurora-A in complex with a new Quinazoline inhibitor

5ZAN の概要

• エントリーDOI: 10.2210/pdb5zan/pdb
• 分子名称: Aurora kinase A, 7-(4-methylpiperazin-1-yl)-N-(5-methyl-1H-pyrazol-3-yl)-2-[(E)-2-phenylethenyl]quinazolin-4-amine (2 entities in total)
• 機能のキーワード: drug design, transferase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32985.88

構造登録者

Cheng, B.,Lu, G.,Zhou, H. (登録日: 2018-02-07, 公開日: 2019-02-13, 最終更新日: 2023-11-22)

• 主引用文献: Long, L.,Peng, W.,Pan, Y.,Cheng, B.,Tu, Z.,Long, Z.,Zhou, H.,Liu, Q.,Lu, G.; Optimization of Novel Quinazolines as Potent and Orally Bioavailable Aurora Kinase Inhibitors; To Be Published,

実験手法

X-RAY DIFFRACTION (2.85 Å)