5ZA7

uPA-HMA

Summary for 5ZA7

• Entry DOI: 10.2210/pdb5za7/pdb
• Descriptor: Urokinase-type plasminogen activator chain B, 3-azanyl-5-(azepan-1-yl)-N-[bis(azanyl)methylidene]-6-chloranyl-pyrazine-2-carboxamide, SULFATE ION, ... (4 entities in total)
• Functional Keywords: urokinase, amiloride, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 28850.21

Authors

Buckley, B.J.,Jiang, L.G.,Huang, M.D.,Kelso, M.J.,Ranson, M. (deposition date: 2018-02-06, release date: 2018-12-19, Last modification date: 2023-11-22)

• Primary citation: Buckley, B.J.,Aboelela, A.,Minaei, E.,Jiang, L.X.,Xu, Z.,Ali, U.,Fildes, K.,Cheung, C.Y.,Cook, S.M.,Johnson, D.C.,Bachovchin, D.A.,Cook, G.M.,Apte, M.,Huang, M.,Ranson, M.,Kelso, M.J.; 6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer.; J. Med. Chem., 61:8299-8320, 2018; PubMed: 30130401; DOI: 10.1021/acs.jmedchem.8b00838

Experimental method

X-RAY DIFFRACTION (1.7 Å)