5Z5V

The first bromodomain of BRD4 with compound BDF-1253

Summary for 5Z5V

• Entry DOI: 10.2210/pdb5z5v/pdb
• Descriptor: Bromodomain-containing protein 4, N-{8-hydroxy-4-[(1H-imidazol-1-yl)methyl]quinolin-2-yl}acetamide (3 entities in total)
• Functional Keywords: brd4, inhibitor, complex, protein binding, transcription-inhibitor complex, transcription/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 15165.49

Authors

Zhang, H.,Luo, C. (deposition date: 2018-01-20, release date: 2019-01-23, Last modification date: 2023-11-22)

• Primary citation: Chen, W.,Zhang, H.,Chen, Z.,Jiang, H.,Liao, L.,Fan, S.,Xing, J.,Xie, Y.,Chen, S.,Ding, H.,Chen, K.,Jiang, H.,Luo, C.,Zheng, M.,Yao, Z.,Huang, Y.,Zhang, Y.; Development and evaluation of a novel series of Nitroxoline-derived BET inhibitors with antitumor activity in renal cell carcinoma.; Oncogenesis, 7:83-83, 2018; PubMed: 30385738; DOI: 10.1038/s41389-018-0093-z

Experimental method

X-RAY DIFFRACTION (1.66 Å)