5Z5T

The first bromodomain of BRD4 with compound BDF-2141

5Z5T の概要

• エントリーDOI: 10.2210/pdb5z5t/pdb
• 分子名称: Bromodomain-containing protein 4, 2-amino-4-(1H-imidazol-1-yl)quinolin-8-ol (3 entities in total)
• 機能のキーワード: brd4, inhibitor, complex, protein binding, transcription-inhibitor complex, transcription/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15109.42

構造登録者

Zhang, H.,Luo, C. (登録日: 2018-01-20, 公開日: 2019-01-23, 最終更新日: 2023-11-22)

• 主引用文献: Chen, W.,Zhang, H.,Chen, Z.,Jiang, H.,Liao, L.,Fan, S.,Xing, J.,Xie, Y.,Chen, S.,Ding, H.,Chen, K.,Jiang, H.,Luo, C.,Zheng, M.,Yao, Z.,Huang, Y.,Zhang, Y.; Development and evaluation of a novel series of Nitroxoline-derived BET inhibitors with antitumor activity in renal cell carcinoma.; Oncogenesis, 7:83-83, 2018; PubMed: 30385738; DOI: 10.1038/s41389-018-0093-z

実験手法

X-RAY DIFFRACTION (1.991 Å)