5Z5O
Structure of Pycnonodysostosis disease related I249T mutant of human cathepsin K
Summary for 5Z5O
Entry DOI | 10.2210/pdb5z5o/pdb |
Related | 1BY8 |
Descriptor | Cathepsin K, GLYCEROL, 1,2-ETHANEDIOL, ... (10 entities in total) |
Functional Keywords | cathepsin k, cysteine protease, lysosomal, bone disorder, pycnodysostosis, hydrolase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 52305.05 |
Authors | Biswas, S.,Roy, S. (deposition date: 2018-01-19, release date: 2018-09-26, Last modification date: 2023-11-22) |
Primary citation | Roy, S.,Das Chakraborty, S.,Biswas, S. Not all pycnodysostosis-related mutants of human cathepsin K are inactive - crystal structure and biochemical studies of an active mutant I249T. FEBS J., 285:4265-4280, 2018 Cited by PubMed: 30199612DOI: 10.1111/febs.14655 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.92 Å) |
Structure validation
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