5Z2T

Crystal structure of DNA-bound DUX4-HD2

Summary for 5Z2T

• Entry DOI: 10.2210/pdb5z2t/pdb
• Descriptor: Double homeobox protein 4, 5'-D(*TP*TP*CP*TP*AP*AP*TP*CP*TP*AP*AP*TP*CP*TP*T)-3', 5'-D(P*AP*AP*GP*AP*TP*TP*AP*GP*AP*TP*TP*AP*GP*T)-3', ... (4 entities in total)
• Functional Keywords: acute lymphoblastic leukemia, dux4/igh, dux4-responsive-element, transactivation, ergalt, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 23424.41

Authors

Dong, X.,Zhang, W.,Wu, H.,Huang, J.,Zhang, M.,Wang, P.,Zhang, H.,Chen, Z.,Chen, S.,Meng, G. (deposition date: 2018-01-04, release date: 2018-04-04, Last modification date: 2023-11-22)

• Primary citation: Dong, X.,Zhang, W.,Wu, H.,Huang, J.,Zhang, M.,Wang, P.,Zhang, H.,Chen, Z.,Chen, S.J.,Meng, G.; Structural basis of DUX4/IGH-driven transactivation.; Leukemia, 32:1466-1476, 2018; PubMed: 29572508; DOI: 10.1038/s41375-018-0093-1

Experimental method

X-RAY DIFFRACTION (2.623 Å)