5Z2P

ThDP-Mn2+ complex of R413K variant of EcMenD soaked with 2-ketoglutarate for 5 min

5Z2P の概要

• エントリーDOI: 10.2210/pdb5z2p/pdb
• 分子名称: 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, (4S)-4-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3lambda~5~-thiazol-2-yl}-4-hydroxybutanoic acid, MANGANESE (II) ION, ... (6 entities in total)
• 機能のキーワード: complex, transferase
• 由来する生物種: Escherichia coli (strain K12)
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 497147.62

構造登録者

Qin, M.M.,Guo, Z.H. (登録日: 2018-01-03, 公開日: 2018-11-28, 最終更新日: 2023-11-22)

• 主引用文献: Qin, M.M.,Song, H.G.,Dai, X.,Chen, Y.Z.,Guo, Z.H.; Two active site arginines are critical determinants of substrate binding and catalysis in MenD: a thiamine-dependent enzyme in menaquinone biosynthesis.; Biochem. J., 475:3651-3667, 2018; PubMed: 30341164; DOI: 10.1042/BCJ20180548

実験手法

X-RAY DIFFRACTION (2.3 Å)