5Z2C

Crystal structure of ALPK-1 N-terminal domain in complex with ADP-heptose

Summary for 5Z2C

• Entry DOI: 10.2210/pdb5z2c/pdb
• Descriptor: Alpha-protein kinase 1, [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2S,3S,4S,5S,6R)-6-[(1S)-1,2-bis(oxidanyl)ethyl]-3,4,5-tris(oxidanyl)oxan-2-yl] hydrogen phosphate (2 entities in total)
• Functional Keywords: pattern recognition receptor, kinase, immune system
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 9
• Total formula weight: 451487.61

Authors

Ding, J.,She, Y.,Shao, F. (deposition date: 2018-01-02, release date: 2018-08-22, Last modification date: 2024-03-27)

• Primary citation: Zhou, P.,She, Y.,Dong, N.,Li, P.,He, H.,Borio, A.,Wu, Q.,Lu, S.,Ding, X.,Cao, Y.,Xu, Y.,Gao, W.,Dong, M.,Ding, J.,Wang, D.C.,Zamyatina, A.,Shao, F.; Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose.; Nature, 561:122-126, 2018; PubMed: 30111836; DOI: 10.1038/s41586-018-0433-3

Experimental method

X-RAY DIFFRACTION (2.594 Å)