5Z2C

Crystal structure of ALPK-1 N-terminal domain in complex with ADP-heptose

5Z2C の概要

分子名称Alpha-protein kinase 1, [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2S,3S,4S,5S,6R)-6-[(1S)-1,2-bis(oxidanyl)ethyl]-3,4,5-tris(oxidanyl)oxan-2-yl] hydrogen phosphate (2 entities in total)
機能のキーワードpattern recognition receptor, kinase, immune system
由来する生物種Homo sapiens (Human)
ポリマー鎖数9
分子量合計451487.61
構造登録者
Ding, J.,She, Y.,Shao, F. (登録日: 2018-01-02, 公開日: 2018-08-22, 最終更新日: 2018-09-19)
主引用文献
Zhou, P.,She, Y.,Dong, N.,Li, P.,He, H.,Borio, A.,Wu, Q.,Lu, S.,Ding, X.,Cao, Y.,Xu, Y.,Gao, W.,Dong, M.,Ding, J.,Wang, D.C.,Zamyatina, A.,Shao, F.
Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose.
Nature, 561:122-126, 2018
PubMed: 30111836 (主引用文献が同じPDBエントリー)
DOI: 10.1038/s41586-018-0433-3
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.594 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.26280.1%4.1%8.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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