5Z1S

Crystal Structure Analysis of the BRD4(1)

Summary for 5Z1S

• Entry DOI: 10.2210/pdb5z1s/pdb
• Descriptor: Bromodomain-containing protein 4, 5-bromo-2-methoxy-N-(6-methoxy-2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl)benzene-1-sulfonamide, NITRATE ION, ... (6 entities in total)
• Functional Keywords: brd4(1), bromodomain, transcription
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 17640.96

Authors

Xu, Y.,Zhang, Y.,Xiang, Q.,Song, M.,Wang, C. (deposition date: 2017-12-28, release date: 2019-01-02, Last modification date: 2024-03-27)

• Primary citation: Xiang, Q.,Zhang, Y.,Li, J.,Xue, X.,Wang, C.,Song, M.,Zhang, C.,Wang, R.,Li, C.,Wu, C.,Zhou, Y.,Yang, X.,Li, G.,Ding, K.,Xu, Y.; Y08060: A Selective BET Inhibitor for Treatment of Prostate Cancer.; Acs Med.Chem.Lett., 9:262-267, 2018; PubMed: 29541371; DOI: 10.1021/acsmedchemlett.8b00003

Experimental method

X-RAY DIFFRACTION (1.42 Å)