5Z1E
MAP2K7 C218S mutant-inhibitor
Summary for 5Z1E
Entry DOI | 10.2210/pdb5z1e/pdb |
Descriptor | Dual specificity mitogen-activated protein kinase kinase 7, N-[3-(6-methyl-1H-indazol-3-yl)phenyl]prop-2-enamide (3 entities in total) |
Functional Keywords | protein kinase, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 37260.16 |
Authors | Kinoshita, T.,London, N. (deposition date: 2017-12-26, release date: 2019-01-02, Last modification date: 2023-11-22) |
Primary citation | Shraga, A.,Olshvang, E.,Davidzohn, N.,Khoshkenar, P.,Germain, N.,Shurrush, K.,Carvalho, S.,Avram, L.,Albeck, S.,Unger, T.,Lefker, B.,Subramanyam, C.,Hudkins, R.L.,Mitchell, A.,Shulman, Z.,Kinoshita, T.,London, N. Covalent Docking Identifies a Potent and Selective MKK7 Inhibitor. Cell Chem Biol, 26:98-108.e5, 2019 Cited by PubMed: 30449673DOI: 10.1016/j.chembiol.2018.10.011 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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