5Z0S
Crystal structure of FGFR1 kinase domain in complex with a novel inhibitor
Summary for 5Z0S
Entry DOI | 10.2210/pdb5z0s/pdb |
Descriptor | Fibroblast growth factor receptor 1, 1-[(6-chloroimidazo[1,2-b]pyridazin-3-yl)sulfonyl]-6-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[4,3-b]pyridine (3 entities in total) |
Functional Keywords | fgfr1 inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 70986.23 |
Authors | |
Primary citation | Jiang, A.,Liu, Q.,Wang, R.,Wei, P.,Dai, Y.,Wang, X.,Xu, Y.,Ma, Y.,Ai, J.,Shen, J.,Ding, J.,Xiong, B. Structure-Based Discovery of a Series of 5H-Pyrrolo[2,3-b]pyrazine FGFR Kinase Inhibitors Molecules, 23:-, 2018 Cited by PubMed: 29562726DOI: 10.3390/molecules23030698 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.45 Å) |
Structure validation
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