5YUP

Crystal Structure of the Fab fragment of FVIIa antibody mAb4F5

5YUP の概要

• エントリーDOI: 10.2210/pdb5yup/pdb
• 分子名称: the heavy chain of the Fab fragment of FVIIa antibody mAb4F5, the light chain of the Fab fragment of FVIIa antibody mAb4F5 (3 entities in total)
• 機能のキーワード: fviia, antibodies, fab4f5, inhibition, coagulation, structural protein, immune system
• 由来する生物種: Mus musculus (mouse); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 47423.72

構造登録者

Jiang, L.G.,Persson, E.,Huang, M.D. (登録日: 2017-11-22, 公開日: 2019-06-19, 最終更新日: 2024-10-23)

主引用文献

Jiang, L.G.,Xie, X.,Li, J.,Persson, E.,Huang, M.D.
Crystal structure, epitope, and functional impact of an antibody against a superactive FVIIa provide insights into allosteric mechanism.
Res Pract Thromb Haemost, 3:412-419, 2019

PubMed Abstract: Blood coagulation factor VIIa (FVIIa) plays its critical physiological role in the initiation of hemostasis. Even so, recombinant FVIIa is successfully used as a bypassing agent for factor VIII or IX in the treatment of bleeds in patients with severe hemophilia with inhibitors. To investigate the utility of more potent FVIIa variants with enhanced intrinsic activity, molecules such as V21D/E154V/M156Q-FVIIa (FVIIa) were designed.

PubMed: 31294329
DOI: 10.1002/rth2.12211

実験手法

X-RAY DIFFRACTION (1.81 Å)