5YU9
Crystal structure of EGFR 696-1022 T790M in complex with Ibrutinib
Summary for 5YU9
Entry DOI | 10.2210/pdb5yu9/pdb |
Related | 4YNJ |
Descriptor | Epidermal growth factor receptor, 1-{(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | egfr, t790m, ibrutinib, inhibitor, oncoprotein |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533 |
Total number of polymer chains | 4 |
Total formula weight | 152470.74 |
Authors | |
Primary citation | Wang, A.,Yan, X.E.,Wu, H.,Wang, W.,Hu, C.,Chen, C.,Zhao, Z.,Zhao, P.,Li, X.,Wang, L.,Wang, B.,Ye, Z.,Wang, J.,Wang, C.,Zhang, W.,Gray, N.S.,Weisberg, E.L.,Chen, L.,Liu, J.,Yun, C.H.,Liu, Q. Ibrutinib targets mutant-EGFR kinase with a distinct binding conformation. Oncotarget, 7:69760-69769, 2016 Cited by PubMed: 27626175DOI: 10.18632/oncotarget.11951 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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