5YT2

Crystal structure of the human vitamin D receptor ligand binding domain complexed with (1R,2S,3R)-5-[(E)-2-{(1R,3aS,7aR)-1-[(R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-yl}vinyl]-2-(3-hydroxypropyl)cyclohex-4-ene-1,3-diol

5YT2 の概要

• エントリーDOI: 10.2210/pdb5yt2/pdb
• 分子名称: Vitamin D3 receptor, (1R,2S,3R)-5-[(E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methyl-6-oxidanyl-heptan-2-yl]-1,2,3,3a,6,7-hexahydroinden-4-yl]ethenyl]-2-(3-oxidanylpropyl)cyclohex-4-ene-1,3-diol (3 entities in total)
• 機能のキーワード: active ligand, complex, transcription
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Nucleus : P11473
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29409.11

構造登録者

Takimoto-Kamimura, M.,Kakuda, S. (登録日: 2017-11-16, 公開日: 2018-04-11, 最終更新日: 2023-11-22)

• 主引用文献: Sawada, D.,Kakuda, S.,Takeuchi, A.,Kawagoe, F.,Takimoto-Kamimura, M.,Kittaka, A.; Effects of 2-substitution on 14-epi-19-nortachysterol-mediated biological events: based on synthesis and X-ray co-crystallographic analysis with the human vitamin D receptor.; Org. Biomol. Chem., 16:2448-2455, 2018; PubMed: 29560490; DOI: 10.1039/C8OB00158H

実験手法

X-RAY DIFFRACTION (2 Å)