5YQX

Crystal Structure Analysis of the BRD4

5YQX の概要

• エントリーDOI: 10.2210/pdb5yqx/pdb
• 分子名称: Bromodomain-containing protein 4, (2R)-2-(cyclopropylmethyl)-7-(3,5-dimethyl-1,2-oxazol-4-yl)-4H-1,4-benzoxazin-3-one, 1,2-ETHANEDIOL, ... (5 entities in total)
• 機能のキーワード: bet, brd4, bromodomain, transcription
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17090.71

構造登録者

Xue, X.,Zhang, Y.,Wang, C.,Song, M. (登録日: 2017-11-08, 公開日: 2018-11-28, 最終更新日: 2024-03-27)

• 主引用文献: Xue, X.,Zhang, Y.,Wang, C.,Zhang, M.,Xiang, Q.,Wang, J.,Wang, A.,Li, C.,Zhang, C.,Zou, L.,Wang, R.,Wu, S.,Lu, Y.,Chen, H.,Ding, K.,Li, G.,Xu, Y.; Benzoxazinone-containing 3,5-dimethylisoxazole derivatives as BET bromodomain inhibitors for treatment of castration-resistant prostate cancer.; Eur.J.Med.Chem., 152:542-559, 2018; PubMed: 29758518; DOI: 10.1016/j.ejmech.2018.04.034

実験手法

X-RAY DIFFRACTION (1.82 Å)