5YQL
Crystal structure of Sirt2 in complex with selective inhibitor A2I
Summary for 5YQL
Entry DOI | 10.2210/pdb5yql/pdb |
Descriptor | NAD-dependent protein deacetylase sirtuin-2, 2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-[3-(phenoxymethyl)phenyl]ethanamide, ZINC ION, ... (5 entities in total) |
Functional Keywords | nad-dependent deacetylase sirtuin-2, inhibitor, complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 35050.82 |
Authors | |
Primary citation | Yang, L.L.,Wang, H.L.,Zhong, L.,Yuan, C.,Liu, S.Y.,Yu, Z.J.,Liu, S.,Yan, Y.H.,Wu, C.,Wang, Y.,Wang, Z.,Yu, Y.,Chen, Q.,Li, G.B. X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells. Eur J Med Chem, 155:806-823, 2018 Cited by PubMed: 29957526DOI: 10.1016/j.ejmech.2018.06.041 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.601 Å) |
Structure validation
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