5YP6

RORgamma (263-509) complexed with SRC2 and Compound 6

Summary for 5YP6

• Entry DOI: 10.2210/pdb5yp6/pdb
• Descriptor: Nuclear receptor ROR-gamma, SRC2, N-[3'-cyano-4'-(2-methylpropyl)-2-(trifluoromethyl)biphenyl-4-yl]-2-[4-(ethylsulfonyl)phenyl]acetamide, ... (4 entities in total)
• Functional Keywords: complex structure, nuclear receptor ror, transcription factor, transcription-inhibitor complex, transcription/inhibitor
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus : P51449
• Total number of polymer chains: 2
• Total formula weight: 30089.92

Authors

Gao, M.,Cai, W. (deposition date: 2017-11-01, release date: 2018-02-07, Last modification date: 2023-11-22)

• Primary citation: Wang, Y.,Cai, W.,Tang, T.,Liu, Q.,Yang, T.,Yang, L.,Ma, Y.,Zhang, G.,Huang, Y.,Song, X.,Orband-Miller, L.A.,Wu, Q.,Zhou, L.,Xiang, Z.,Xiang, J.N.,Leung, S.,Shao, L.,Lin, X.,Lobera, M.,Ren, F.; From ROR gamma t Agonist to Two Types of ROR gamma t Inverse Agonists; ACS Med Chem Lett, 9:120-124, 2018; PubMed: 29456799; DOI: 10.1021/acsmedchemlett.7b00476

Experimental method

X-RAY DIFFRACTION (2.2 Å)