5YP5

Crystal structure of RORgamma complexed with SRC2 and compound 5d

Summary for 5YP5

Entry DOI	10.2210/pdb5yp5/pdb
Descriptor	Nuclear receptor ROR-gamma, SRC2-2 peptide, 2-[4-(ethylsulfonyl)phenyl]-N-{5-[2-(2-methylpropyl)benzoyl]-4-phenyl-1,3-thiazol-2-yl}acetamide, ... (4 entities in total)
Functional Keywords	complex structure, nuclear receptor ror, transcription factor, transcription-inhibitor complex, transcription/inhibitor
Biological source	Homo sapiens (Human) More
Cellular location	Nucleus : P51449
Total number of polymer chains	2
Total formula weight	29877.82
Authors	Gao, M.,Cai, W.,Chunwa, C. (deposition date: 2017-11-01, release date: 2018-04-04, Last modification date: 2024-03-27)
Primary citation	Wang, Y.,Cai, W.,Tang, T.,Liu, Q.,Yang, T.,Yang, L.,Ma, Y.,Zhang, G.,Huang, Y.,Song, X.,Orband-Miller, L.A.,Wu, Q.,Zhou, L.,Xiang, Z.,Xiang, J.N.,Leung, S.,Shao, L.,Lin, X.,Lobera, M.,Ren, F. From ROR gamma t Agonist to Two Types of ROR gamma t Inverse Agonists ACS Med Chem Lett, 9:120-124, 2018 Cited by PubMed: 29456799 DOI: 10.1021/acsmedchemlett.7b00476 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.65 Å)

Structure validation