5YOV

Crystal structure of BRD4-BD1 bound with hjp126

5YOV の概要

• エントリーDOI: 10.2210/pdb5yov/pdb
• 分子名称: Bromodomain-containing protein 4, (3~{R})-4-cyclopentyl-~{N}-(2,4-dimethylphenyl)-1,3-dimethyl-2-oxidanylidene-3~{H}-quinoxaline-6-carboxamide (3 entities in total)
• 機能のキーワード: bromodomain, transcription-inhibitor complex, transcription/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15490.89

構造登録者

Xiong, B.,Hu, J.,Li, Y.,Cao, D. (登録日: 2017-10-31, 公開日: 2018-11-07, 最終更新日: 2024-03-27)

• 主引用文献: Hu, J.,Wang, Y.,Li, Y.,Cao, D.,Xu, L.,Song, S.,Damaneh, M.S.,Li, J.,Chen, Y.,Wang, X.,Chen, L.,Shen, J.,Miao, Z.,Xiong, B.; Structure-based optimization of a series of selective BET inhibitors containing aniline or indoline groups.; Eur.J.Med.Chem., 150:156-175, 2018; PubMed: 29525435; DOI: 10.1016/j.ejmech.2018.02.070

実験手法

X-RAY DIFFRACTION (1.451 Å)