5YNB

Crystal structure of MERS-CoV nsp16/nsp10 complex bound to Sinefungin

Summary for 5YNB

Descriptornsp16 protein, nsp10 protein, SINEFUNGIN, ... (5 entities in total)
Functional Keywordsinhibitor, complex, transferase
Biological sourceHuman betacoronavirus 2c EMC/2012
Total number of polymer chains2
Total molecular weight49152.7
Authors
Wei, S.M.,Yang, L.,Ke, Z.H.,Chen, Y.,Guo, D.Y.,Fan, C.P. (deposition date: 2017-10-24, release date: 2018-12-05)
Primary citation
Wei, S.M.,Yang, L.,Ke, Z.H.,Liu, Q.Y.,Chen, Y.,Yang, Z.Z.,Guo, D.Y.,Fan, C.P.
Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex
To Be Published,
Experimental method
X-RAY DIFFRACTION (1.98 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2212 0.2% 1.2% 9.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution