5YLS

Crystal structure of T2R-TTL-Y50 complex

5YLS の概要

• エントリーDOI: 10.2210/pdb5yls/pdb
• 分子名称: Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, E-3-(3-azanyl-4-methoxy-phenyl)-1-(5-methoxy-2,2-dimethyl-chromen-8-yl)prop-2-en-1-one, ... (13 entities in total)
• 機能のキーワード: colchicine binding domain, tubulin inhibitor, tublin, millepachine, structural protein
• 由来する生物種: Sus scrofa (Pig); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 265344.82

構造登録者

Yang, J.H.,Chen, L.J. (登録日: 2017-10-18, 公開日: 2018-04-11, 最終更新日: 2024-03-27)

• 主引用文献: Yang, J.H.,Yan, W.,Yu, Y.M.,Wang, Y.X.,Yang, T.,Xue, L.L.,Yuan, X.,Long, C.F.,Liu, Z.W.,Chen, X.X.,Hu, M.S.,Zheng, L.,Qiu, Q.,Pei, H.Y.,Li, D.,Wang, F.,Bai, P.,Wen, J.L.,Ye, H.Y.,Chen, L.J.; The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in beta-tubulin.; J. Biol. Chem., 293:9461-9472, 2018; PubMed: 29691282; DOI: 10.1074/jbc.RA117.001658

実験手法

X-RAY DIFFRACTION (3 Å)