5YL2
Crystal structure of T2R-TTL-Y28 complex
Summary for 5YL2
Entry DOI | 10.2210/pdb5yl2/pdb |
Descriptor | Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, (E)-1-(5-methoxy-2,2-dimethyl-chromen-8-yl)-3-(4-methoxy-3-oxidanyl-phenyl)prop-2-en-1-one, ... (13 entities in total) |
Functional Keywords | colchicine binding domain, tubulin inhibitor, tublin, millepachine, structural protein |
Biological source | Sus scrofa (Pig) More |
Cellular location | Cytoplasm, cytoskeleton: Q2XVP4 A0A287AGU7 Golgi apparatus : P63043 |
Total number of polymer chains | 6 |
Total formula weight | 265346.79 |
Authors | Yang, J.H.,Yang, T.,Wen, J.L.,Chen, L.J. (deposition date: 2017-10-16, release date: 2018-04-18, Last modification date: 2024-03-27) |
Primary citation | Jianhong, Y.,Wei, Y.,Yamei, Y.,Yuxi, W.,Tao, Y.,Linlin, X.,Xue, Y.,Caofeng, L.,Zuowei, L.,Xiaoxin, C.,Mengshi, H.,Li, Z.,Qiang, Q.,Heying, P.,Dan, L.,Fang, W.,Peng, B.,Jiaolin, W.,Haoyu, Y.,Lijuan, C. The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in beta-tubulin. J. Biol. Chem., 2018 Cited by PubMed: 29691282DOI: 10.1074/jbc.RA117.001658 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.09 Å) |
Structure validation
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