5YKP

Human methionine aminopeptidase type 1b (F309M mutant) in complex with ovalicin

Summary for 5YKP

DescriptorMethionine aminopeptidase 1, COBALT (II) ION, POTASSIUM ION, ... (5 entities in total)
Functional Keywordsselective inhibition, streptococcal pneumoniae, enterococcus feacalis, metal binding protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total molecular weight34774.31
Authors
Arya, T.,Pillalamarri, V.,Addlagatta, A. (deposition date: 2017-10-15, release date: 2018-10-17, Last modification date: 2019-04-03)
Primary citation
Pillalamarri, V.,Arya, T.,Haque, N.,Bala, S.C.,Marapaka, A.K.,Addlagatta, A.
Discovery of natural product ovalicin sensitive type 1 methionine aminopeptidases: molecular and structural basis.
Biochem. J., 476:991-1003, 2019
PubMed: 30837307 (PDB entries with the same primary citation)
DOI: 10.1042/BCJ20180874
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.68 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2233 0.3% 2.3% 6.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 5ykp
no rotation
Molmil generated image of 5ykp
rotated about x axis by 90°
Molmil generated image of 5ykp
rotated about y axis by 90°