5YJP

Human chymase in complex with 3-(ethoxyimino)-7-oxo-1,4-diazepane derivative

Summary for 5YJP

Entry DOI	10.2210/pdb5yjp/pdb
Descriptor	human chymase, 2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (5 entities in total)
Functional Keywords	protease, inhibitor, complex, hydrolase
Biological source	Homo sapiens
Total number of polymer chains	1
Total formula weight	26071.74
Authors	Sugawara, H. (deposition date: 2017-10-11, release date: 2017-12-27, Last modification date: 2020-07-29)
Primary citation	Futamura-Takahashi, J.,Tanaka, T.,Sugawara, H.,Iwashita, S.,Imajo, S.,Oyama, Y.,Muto, T. Structure-based design, synthesis, and binding mode analysis of novel and potent chymase inhibitors Bioorg. Med. Chem. Lett., 28:188-192, 2018 Cited by PubMed: 29191554 DOI: 10.1016/j.bmcl.2017.11.031 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation