5YGI

Crystal structure of human FPPS in complex with an inhibitor THZ93

Summary for 5YGI

DescriptorFarnesyl pyrophosphate synthase, PHOSPHATE ION, MAGNESIUM ION, ... (5 entities in total)
Functional Keywordsthz93, complex, human fpps, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total molecular weight40660.81
Authors
Li, X. (deposition date: 2017-09-23, release date: 2018-09-26, Last modification date: 2019-04-10)
Primary citation
Xia, Y.,Xie, Y.,Yu, Z.,Xiao, H.,Jiang, G.,Zhou, X.,Yang, Y.,Li, X.,Zhao, M.,Li, L.,Zheng, M.,Han, S.,Zong, Z.,Meng, X.,Deng, H.,Ye, H.,Fa, Y.,Wu, H.,Oldfield, E.,Hu, X.,Liu, W.,Shi, Y.,Zhang, Y.
The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery.
Cell, 175:1059-1073.e21, 2018
PubMed: 30270039 (PDB entries with the same primary citation)
DOI: 10.1016/j.cell.2018.08.070
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.177 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.27290 2.8% 6.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution