5YGI

Crystal structure of human FPPS in complex with an inhibitor THZ93

5YGI の概要

• エントリーDOI: 10.2210/pdb5ygi/pdb
• 分子名称: Farnesyl pyrophosphate synthase, PHOSPHATE ION, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: thz93, complex, human fpps, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40660.81

構造登録者

Li, X. (登録日: 2017-09-23, 公開日: 2018-09-26, 最終更新日: 2024-03-27)

• 主引用文献: Xia, Y.,Xie, Y.,Yu, Z.,Xiao, H.,Jiang, G.,Zhou, X.,Yang, Y.,Li, X.,Zhao, M.,Li, L.,Zheng, M.,Han, S.,Zong, Z.,Meng, X.,Deng, H.,Ye, H.,Fa, Y.,Wu, H.,Oldfield, E.,Hu, X.,Liu, W.,Shi, Y.,Zhang, Y.; The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery.; Cell, 175:1059-1073.e21, 2018; PubMed: 30270039; DOI: 10.1016/j.cell.2018.08.070

実験手法

X-RAY DIFFRACTION (2.177 Å)