5YCE

Sperm whale myoglobin swMb

5YCE の概要

• エントリーDOI: 10.2210/pdb5yce/pdb
• 分子名称: Myoglobin, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: globin, molecular archaeology, ancient protein, protein evolution, deep-sea adaptation, oxygen storage
• 由来する生物種: Physeter catodon (Sperm whale)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 18270.82

構造登録者

Isogai, Y.,Imamura, H.,Nakae, S.,Sumi, T.,Takahashi, K.,Nakagawa, T.,Tsuneshige, A.,Shirai, T. (登録日: 2017-09-07, 公開日: 2018-09-19, 最終更新日: 2023-11-22)

主引用文献

Isogai, Y.,Imamura, H.,Nakae, S.,Sumi, T.,Takahashi, K.I.,Nakagawa, T.,Tsuneshige, A.,Shirai, T.
Tracing whale myoglobin evolution by resurrecting ancient proteins.
Sci Rep, 8:16883-16883, 2018

PubMed Abstract: Extant cetaceans, such as sperm whale, acquired the great ability to dive into the ocean depths during the evolution from their terrestrial ancestor that lived about 50 million years ago. Myoglobin (Mb) is highly concentrated in the myocytes of diving animals, in comparison with those of land animals, and is thought to play a crucial role in their adaptation as the molecular aqualung. Here, we resurrected ancestral whale Mbs, which are from the common ancestor between toothed and baleen whales (Basilosaurus), and from a further common quadrupedal ancestor between whale and hippopotamus (Pakicetus). The experimental and theoretical analyses demonstrated that whale Mb adopted two distinguished strategies to increase the protein concentration in vivo along the evolutionary history of deep sea adaptation; gaining precipitant tolerance in the early phase of the evolution, and increase of folding stability in the late phase.

PubMed: 30442991
DOI: 10.1038/s41598-018-34984-6

実験手法

X-RAY DIFFRACTION (0.77 Å)