5YC3

Crystal structure of AL3 PHD finger bound to H3K4me2

5YC3 の概要

• エントリーDOI: 10.2210/pdb5yc3/pdb
• 分子名称: PHD finger protein ALFIN-LIKE 3, H3K4me2, ZINC ION, ... (4 entities in total)
• 機能のキーワード: phd finger, transcription
• 由来する生物種: Arabidopsis thaliana (Mouse-ear cress); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 7749.49

構造登録者

Zhao, S.,Zhang, B.,Li, H. (登録日: 2017-09-06, 公開日: 2018-01-24, 最終更新日: 2023-11-22)

主引用文献

Zhao, S.,Zhang, B.,Yang, M.,Zhu, J.,Li, H.
Systematic Profiling of Histone Readers in Arabidopsis thaliana.
Cell Rep, 22:1090-1102, 2018

PubMed Abstract: Histone post-translational modifications (PTMs) and their recognition by histone readers exert crucial functions in eukaryotes. Despite extensive studies, conservation and diversity of histone PTM regulation between animals and plants remain less explored because of a lack of systematic knowledge of histone readers in plants. Based on a high-throughput surface plasmon resonance imaging (SPRi) platform, we report the lab-on-chip profiling of interactions between 204 putative reader domains and 11 types of histone peptides in Arabidopsis thaliana. Eleven reader hits were then chosen for histone combinatorial readout pattern profiling. Systematic analysis of histone PTM recognition in Arabidopsis thaliana reveals that plant and human histone readers share conservation in domain types and recognition mechanisms. The differences in particular histone mark recognition by transcription regulator EML1 and DNA damage repair factor MSH6 indicate plant-specific histone PTMs function in Arabidopsis thaliana acquired during evolution.

PubMed: 29386129
DOI: 10.1016/j.celrep.2017.12.099

実験手法

X-RAY DIFFRACTION (2.601 Å)