5Y9T

Crystal Structure of EGFR T790M mutant in complex with naquotinib

5Y9T の概要

• エントリーDOI: 10.2210/pdb5y9t/pdb
• 分子名称: Epidermal growth factor receptor, 6-ethyl-3-[[4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]-5-[(3R)-1-prop-2-enoylpyrrolidin-3-yl]oxy-pyrazin e-2-carboxamide (2 entities in total)
• 機能のキーワード: kinase, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38468.55

構造登録者

Mimasu, S.,Tomimoto, Y.,Maiko, I.,Yasushi, A.,Tatsuya, N. (登録日: 2017-08-28, 公開日: 2018-07-11, 最終更新日: 2023-11-22)

• 主引用文献: Hirano, T.,Yasuda, H.,Hamamoto, J.,Nukaga, S.,Masuzawa, K.,Kawada, I.,Naoki, K.,Niimi, T.,Mimasu, S.,Sakagami, H.,Soejima, K.,Betsuyaku, T.; Pharmacological and Structural Characterizations of Naquotinib, a Novel Third-Generation EGFR Tyrosine Kinase Inhibitor, inEGFR-Mutated Non-Small Cell Lung Cancer.; Mol. Cancer Ther., 17:740-750, 2018; PubMed: 29467275; DOI: 10.1158/1535-7163.MCT-17-1033

実験手法