5Y93

Crystal Structure Analysis of the BRD4

5Y93 の概要

• エントリーDOI: 10.2210/pdb5y93/pdb
• 分子名称: Bromodomain-containing protein 4, 2-[[5-[(5-bromanyl-2-methoxy-phenyl)sulfonylamino]-3-methyl-1,2-benzoxazol-6-yl]oxy]-N-(2-morpholin-4-ylethyl)ethanamide, NITRATE ION, ... (6 entities in total)
• 機能のキーワード: brd4(1), bromodomain, transcription
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17721.04

構造登録者

Xu, Y.,Zhang, Y.,Song, M.,Wang, C. (登録日: 2017-08-22, 公開日: 2018-06-13, 最終更新日: 2024-03-27)

• 主引用文献: Zhang, M.,Zhang, Y.,Song, M.,Xue, X.,Wang, J.,Wang, C.,Zhang, C.,Li, C.,Xiang, Q.,Zou, L.,Wu, X.,Wu, C.,Dong, B.,Xue, W.,Zhou, Y.,Chen, H.,Wu, D.,Ding, K.,Xu, Y.; Structure-Based Discovery and Optimization of Benzo[ d]isoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC); J. Med. Chem., 61:3037-3058, 2018; PubMed: 29566488; DOI: 10.1021/acs.jmedchem.8b00103

実験手法

X-RAY DIFFRACTION (1.62 Å)