5Y6D
VIM-2 metallo-beta-lactamase in complex with (R)-2-(4-fluorophenyl)-2-((S)-3-mercapto-2-methylpropanamido)acetic acid (compound 11)
Summary for 5Y6D
| Entry DOI | 10.2210/pdb5y6d/pdb |
| Descriptor | Beta-lactamase class B VIM-2, ZINC ION, (2R)-2-(4-fluorophenyl)-2-[[(2S)-2-methyl-3-sulfanyl-propanoyl]amino]ethanoic acid, ... (5 entities in total) |
| Functional Keywords | beta-lactamase, metallo-beta-lactamase vim-2, vim-2, hydrolase |
| Biological source | Pseudomonas aeruginosa |
| Total number of polymer chains | 4 |
| Total formula weight | 100437.69 |
| Authors | Li, G.-B. (deposition date: 2017-08-11, release date: 2018-01-24, Last modification date: 2023-11-22) |
| Primary citation | Liu, S.,Jing, L.,Yu, Z.-J.,Wu, C.,Zheng, Y.,Zhang, E.,Chen, Q.,Yu, Y.,Guo, L.,Wu, Y.,Li, G.-B. ((S)-3-Mercapto-2-methylpropanamido)acetic acid derivatives as metallo-beta-lactamase inhibitors: Synthesis, kinetic and crystallographic studies. Eur J Med Chem, 145:649-660, 2018 Cited by PubMed: 29353720DOI: 10.1016/j.ejmech.2018.01.032 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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