5Y56

Fc mutant (K392D/K409D/D399K)

Summary for 5Y56

• Entry DOI: 10.2210/pdb5y56/pdb
• Descriptor: Immunoglobulin gamma-1 heavy chain, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-beta-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[beta-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: igg fc, homodimer, triple mutantion (k392d/k409d/d399k), immune system
• Biological source: Homo sapiens (Human)
• Cellular location: Secreted : P0DOX5
• Total number of polymer chains: 2
• Total formula weight: 50082.76

Authors

Ye, S.,Xu, T.,Yu, J.,Wang, X.,Xu, T.,Jin, Q.,Duan, J.,Wu, J.,Wu, H. (deposition date: 2017-08-07, release date: 2017-09-13, Last modification date: 2023-11-22)

• Primary citation: Yu, J.,Wang, X.,Xu, T.,Jin, Q.,Duan, J.,Wu, J.,Wu, H.,Xu, T.,Ye, S.; A rational approach to enhancing antibody Fc homodimer formation for robust production of antibody mixture in a single cell line; J. Biol. Chem., 292:17885-17896, 2017; PubMed: 28878018; DOI: 10.1074/jbc.M116.771188

Experimental method

X-RAY DIFFRACTION (2.653 Å)