5Y56
Fc mutant (K392D/K409D/D399K)
5Y56 の概要
エントリーDOI | 10.2210/pdb5y56/pdb |
分子名称 | Immunoglobulin gamma-1 heavy chain, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-beta-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[beta-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total) |
機能のキーワード | igg fc, homodimer, triple mutantion (k392d/k409d/d399k), immune system |
由来する生物種 | Homo sapiens (Human) |
細胞内の位置 | Secreted : P0DOX5 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 50082.76 |
構造登録者 | |
主引用文献 | Yu, J.,Wang, X.,Xu, T.,Jin, Q.,Duan, J.,Wu, J.,Wu, H.,Xu, T.,Ye, S. A rational approach to enhancing antibody Fc homodimer formation for robust production of antibody mixture in a single cell line J. Biol. Chem., 292:17885-17896, 2017 Cited by PubMed: 28878018DOI: 10.1074/jbc.M116.771188 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.653 Å) |
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