5Y56

Fc mutant (K392D/K409D/D399K)

5Y56 の概要

• エントリーDOI: 10.2210/pdb5y56/pdb
• 分子名称: Immunoglobulin gamma-1 heavy chain, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-beta-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[beta-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: igg fc, homodimer, triple mutantion (k392d/k409d/d399k), immune system
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Secreted : P0DOX5
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 50082.76

構造登録者

Ye, S.,Xu, T.,Yu, J.,Wang, X.,Xu, T.,Jin, Q.,Duan, J.,Wu, J.,Wu, H. (登録日: 2017-08-07, 公開日: 2017-09-13, 最終更新日: 2023-11-22)

• 主引用文献: Yu, J.,Wang, X.,Xu, T.,Jin, Q.,Duan, J.,Wu, J.,Wu, H.,Xu, T.,Ye, S.; A rational approach to enhancing antibody Fc homodimer formation for robust production of antibody mixture in a single cell line; J. Biol. Chem., 292:17885-17896, 2017; PubMed: 28878018; DOI: 10.1074/jbc.M116.771188

実験手法

X-RAY DIFFRACTION (2.653 Å)