5Y3Q
Crystal structure of SARS coronavirus papain-like protease conjugated with beta-mercaptoethanol
Summary for 5Y3Q
Entry DOI | 10.2210/pdb5y3q/pdb |
Descriptor | Replicase polyprotein 1a, ZINC ION, BETA-MERCAPTOETHANOL, ... (6 entities in total) |
Functional Keywords | complex structure, hydrolase |
Biological source | Human SARS coronavirus (SARS-CoV) |
Cellular location | Non-structural protein 3: Host membrane ; Multi-pass membrane protein . Non-structural protein 4: Host membrane ; Multi-pass membrane protein . Non-structural protein 6: Host membrane ; Multi-pass membrane protein . Non-structural protein 7: Host cytoplasm, host perinuclear region . Non-structural protein 8: Host cytoplasm, host perinuclear region . Non-structural protein 9: Host cytoplasm, host perinuclear region . Non-structural protein 10: Host cytoplasm, host perinuclear region : P0C6U8 |
Total number of polymer chains | 1 |
Total formula weight | 36904.91 |
Authors | Lin, M.H.,Chou, C.Y. (deposition date: 2017-07-29, release date: 2018-01-10, Last modification date: 2023-11-22) |
Primary citation | Lin, M.H.,Moses, D.C.,Hsieh, C.H.,Cheng, S.C.,Chen, Y.H.,Sun, C.Y.,Chou, C.Y. Disulfiram can inhibit MERS and SARS coronavirus papain-like proteases via different modes Antiviral Res., 150:155-163, 2017 Cited by PubMed: 29289665DOI: 10.1016/j.antiviral.2017.12.015 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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