5Y3O
Structure of TRAP1 complexed with DN320
Summary for 5Y3O
Entry DOI | 10.2210/pdb5y3o/pdb |
Descriptor | Heat shock protein 75 kDa, mitochondrial, 4-chloranyl-1-[(4-methoxy-3,5-dimethyl-pyridin-2-yl)methyl]pyrazolo[3,4-d]pyrimidin-6-amine (3 entities in total) |
Functional Keywords | trap1, inhibitor, dn320, mitochondrial hsp90, chaperone |
Biological source | Homo sapiens (Human) |
Cellular location | Mitochondrion : Q12931 |
Total number of polymer chains | 1 |
Total formula weight | 57740.85 |
Authors | Jeong, H.,Park, H.K.,Kang, S.,Kang, B.H.,Lee, C. (deposition date: 2017-07-29, release date: 2017-08-30, Last modification date: 2024-03-27) |
Primary citation | Park, H.K.,Jeong, H.,Ko, E.,Lee, G.,Lee, J.E.,Lee, S.K.,Lee, A.J.,Im, J.Y.,Hu, S.,Kim, S.H.,Lee, J.H.,Lee, C.,Kang, S.,Kang, B.H. Paralog Specificity Determines Subcellular Distribution, Action Mechanism, and Anticancer Activity of TRAP1 Inhibitors. J. Med. Chem., 60:7569-7578, 2017 Cited by PubMed: 28816449DOI: 10.1021/acs.jmedchem.7b00978 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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