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5Y2F

Human SIRT6 in complex with allosteric activator MDL-801

Summary for 5Y2F
Entry DOI10.2210/pdb5y2f/pdb
DescriptorNAD-dependent protein deacetylase sirtuin-6, 9-mer peptide QTARKSTGG, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE, ... (10 entities in total)
Functional Keywordsagnonist, complex, sirt6, hydrolase-peptide complex, hydrolase/peptide
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains2
Total formula weight38676.62
Authors
Zhang, J.,Huang, Z.,Song, K. (deposition date: 2017-07-25, release date: 2018-11-07, Last modification date: 2018-11-28)
Primary citationHuang, Z.,Zhao, J.,Deng, W.,Chen, Y.,Shang, J.,Song, K.,Zhang, L.,Wang, C.,Lu, S.,Yang, X.,He, B.,Min, J.,Hu, H.,Tan, M.,Xu, J.,Zhang, Q.,Zhong, J.,Sun, X.,Mao, Z.,Lin, H.,Xiao, M.,Chin, Y.E.,Jiang, H.,Xu, Y.,Chen, G.,Zhang, J.
Identification of a cellularly active SIRT6 allosteric activator.
Nat. Chem. Biol., 14:1118-1126, 2018
Cited by
PubMed: 30374165
DOI: 10.1038/s41589-018-0150-0
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.53 Å)
Structure validation

217705

數據於2024-03-27公開中

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