5Y1Q

Crystal structure of Plasmodium falciparum aminopeptidase N in complex with (S)-2-(3-(3-chlorobenzyl)ureido)-N-hydroxy-4-methylpentanamide

Summary for 5Y1Q

Entry DOI	10.2210/pdb5y1q/pdb
Descriptor	M1 family aminopeptidase, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	m1-class aminopeptidase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Plasmodium falciparum
Total number of polymer chains	1
Total formula weight	106743.58
Authors	Marapaka, A.K.,Zhang, Y.,Addlagatta, A. (deposition date: 2017-07-21, release date: 2018-08-01, Last modification date: 2023-11-22)
Primary citation	Marapaka, A.K.,Sankoju, P.,Zhang, G.,Ding, Y.,Ma, C.,Pillalamarri, V.,Sudhakar, P.,Reddi, B.,Sijwali, P.S.,Zhang, Y.,Addlagatta, A. Development of peptidomimetic hydroxamates as PfA-M1 and PfA-M17 dual inhibitors: Biological evaluation and structural characterization by cocrystallization Chin.Chem.Lett., 33:2550-2554, 2022 Cited by DOI: 10.1016/j.cclet.2021.09.102 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.14 Å)

Structure validation